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The Science


At KetoNatural, part of our mission is to be the most substantive pet food company in the world. That means making products with real benefits and demonstrating those benefits using real evidence.

As part of this commitment, we've compiled the largest free library of evidence-based pet nutrition resources on the Internet. Articles, e-books, videos, research summaries, full-text studies, and more (we even include free downloadable copies of "Dogs, Dog Food, and Dogma," the revolutionary book by KetoNatural founder Daniel Schulof). It's everything modern pet owners need in order to make smart, sensible nutrition and lifestyle choices for their canine companions. 

 In exchange for access, all we ask is that you join our e-mail list. We promise to be respectful of your time and your privacy. We'll send you our five-part intro to the science of canine carbohydrate restriction, as well as updates from the company. You can unsubscribe at any time. And if you'd rather not join, well, we're okay with that too. It's not a rule, just a request.

 


Carbohydrates and Fattening/Obesity

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KNPF Evidence Review White Paper

Are carbohydrates more fattening for dogs than other nutrients?

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KNPF Evidence Review White Paper

Does carbohydrate consumption induce metabolic and hormonal changes in dogs? 

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Dietz et al. 2002

"Weight Loss in Obese Dogs: Evaluation of a High-Protein, Low-Carbohydrate Diet." Journal of Nutrition.

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Bierer et al. 2004

"High-Protein, Low-Carbohydrate Diets Enhance Weight Loss in Dogs." Journal of Nutrition.

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Bazzano et al. 2014

"Effects of Low-Carbohydrate and Low-Fat Diets: A Randomized Trial." Annals of Internal Medicine.

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Gardner et al. 2007

"Comparison of the Atkins, Zone, Ornish, and LEARN Diets for Change in Weight and Related Risk Factors Among Overweight Premenopausal Women.” JAMA.

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Bergman et al. 2003

"Primacy of Hepatic Inuslin Resistance in the Development of the Metabolic Syndrome Induced by an Isocaloric Moderate-Fat Diet in the Dog.” Diabetes.

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Good Calories, Bad Calories

Gary Taubes (2007, Random House).

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Why We Get Fat And What To Do About It

Gary Taubes (2010, Random House).

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Always Hungry?

David Ludwig, MD, PhD (2016, Hachette)

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VIDEO

Gary Taubes on the Carbohydrate/Insulin Model of Obesity (2011).

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VIDEO

"Sugar: The Bitter Truth." Robert Lustig, MD (2009).

Protein Consumption

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KNPF Evidence Review White Paper

Does High Protein Consumption Damage Kidney Function?

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Bovee 1999

“Mythology of Protein Restriction for Dogs with Reduced Renal Function.” Supplement to Compendium on Continuing Education for the Practicing Veterinarian.

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Finco et al. 1994

“Effects of Aging and Dietary Protein Intake on Uniephrectomized Geriatric Dogs.” American Journal of Veterinary Research.

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Bovee 1991

“Influence of Dietary Protein on Renal Function in Dogs.” Journal of Nutrition.

Wolves and Canine Evolution

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KNPF Evidence Review White Paper

Wolves and Carbohydrate Consumption

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Axelsson et al. 2013

"The Genomic Signature of Dog Domestication Reveals Adaptation to a Starch-Rich Diet." Nature.

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Abegglen et al. 2015

"Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans." JAMA.

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Eaton et al. 1985

"Paleolithic Nutrition - A Consideration of Its Nature And Current Implications." New England Journal of Medicine.

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Hilderbrand et al. 2013

"Body Composition of Free-Ranging Wolves." Canadian Journal of Zoology.

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Wolves: Behavior, Ecology, and Conservation

L. David Mech & Luigi Boitani (2003, University of Chicago Press).

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Body Composition in Animals and Man

National Research Council (1968).

Carbohydrate Consumption and Disease

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KNPF Evidence Review White Paper

Ketogenic Diets and Canine Cancer

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KNPF Evidence Review White Paper

Ketogenic Diets and Canine Epilepsy

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Kealy et al. 2002

"Effects of Diet Restriction on Lifespan and Age-Related Changes in Dogs." Journal of the American Veterinary Medical Association.

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Dehgham et al. 2017

"Associations of Fats and Carbohydrate Intake With Cardiovascular Disease and Mortality in 18 Countries From Five Continents (PURE): A Prospective Cohort Study." Lancet.

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Dirx et al. 2003

“Energy Restricition and the Risk of Spontaneous Mammary Tumors in Mice: A Meta-Analysis.” International Journal of Cancer.

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Kealy et al. 1997

"Five-year longitudinal study on limited food consumption and development of osteoarthritis in coxofemoral joints of dogs." Journal of the American Veterinary Medical Association.

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Guan et al. 2014

“Roles of Caloric Restriction, Ketogenic Diet and Intermittent Fasting During Initiation, Progression and Metastasis of Cancer in Animal Models: A Systematic Review and Meta-Analysis.” PLoS One.

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Klement et al. 2016

“Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis.” PLoS One.

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Kroemer et al. 2008

“Tumor Cell Metabolism: Cancer’s Achilles’ Heel.” Cancer Cell.

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Ristow et al. 2017

 “Dietary Carbohydrates Impair Healthspan and Promote Mortality." Cell Metabolism.

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Seyfried 2015

“Cancer as a Mitochondrial Metabolic Disease.” Frontiers in Cell and Development Biology.

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VIDEO

Dr. Dominic D'Agostino on Starving Cancer Cells

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VIDEO

Dr. Thomas Seyfried on the Metabolic Theory of Cancer.

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VIDEO

Dr. Thomas Seyfried on Nutritional Treatments for Canine Cancer.

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VIDEO

Dr. Craig Thompson, Memorial Sloan Kettering Cancer Center CEO, on Links Between Carbohydrates and Cancer

Raw Food Diets

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KNPF Evidence Review White Paper

The Benefits For Dogs and Cats of Raw Ingredient Diets

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KNPF Evidence Review White Paper

The Costs of Raw Ingredient Diets

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Freeman et al. 2013

“Current Knowledge About the Risks and Benefits of Raw Meat-Based Diets For Dogs and Cats.” Journal of the American Veterinary Medical Association.

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Schlesinger et al. 2011

“Raw Food Diets in Companion Animals: A Critical Review.” Canadian Veterinary Journal.

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Kerr et al. 2012

“Apparent Total Tract Energy and Macronutrient Digestibility and Fecal Fermentative End-Product Concentrations of Domestic Cats Fed Extruded, Raw Beef-Based, and Cooked Beef-Based Diets.” Journal of Animal Sciences.

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Behravesh et al. 2011

“Human Salmonella Infections Linked to Contaminated Dry Dog and Cat Food, 2006-2008.” Pediatrics.

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Joffe et al. 2002

“Preliminary Assessment of the Risk of Salmonella Infection in Dogs Fed Raw Chicken Diets.” Canadian Veterinary Journal.

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Lenz et al. 2009

“Perceptions, Practices, and Consequences Associated With Foodborne Pathogens and the Feeding of Raw Meat to Dogs.” Canadian Veterinary Journal.

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American College of Veterinary Nutrition

Website FAQ on Raw Diets

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American Animal Hospital Association

Statement on Raw Protein Diets.

Additional Consumer Resources

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Body Condition Scoring Chart

Evidence-based canine body condition analysis tool.

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Canine Obesity Infographic

Facts and figures on canine obesity.

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AAFCO Consumer Assistance

Various consumer resources from the Association of American Feed Control Officials.

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ACVN Consumer FAQs

Information concerning pet food labeling and animal nutritional needs from the American College of Veterinary Nutrition.

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Dogs, Dog Food, and Dogma -- .EPUB Version

For use with all e-readers except for Kindle. Dogs, Dog Food, and Dogma: The Silent Epidemic Killing America's Dogs and the New Science That Could Save Your Best Friend's Life. Daniel Schulof (Present Tense Press, 2016).

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Dogs, Dog Food, and Dogma -- .MOBI Version

For use with Kindle e-readers. Dogs, Dog Food, and Dogma: The Silent Epidemic Killing America's Dogs and the New Science That Could Save Your Best Friend's Life. Daniel Schulof (Present Tense Press, 2016).